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KMID : 0361020080510050453
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Korean Journal of Otolaryngology - Head and Neck Surgery
2008 Volume.51 No. 5 p.453 ~ p.458
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Clinical Significance of Retrolharyngeal Lymph Node Metastasis from Hypopharyngeal Squamous Cell Carcinoma
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Yu Myeong-Sang
Choi Seung-Ho
Kim Sang-Yoon
Nam Soon-Yuhl
Roh Jong-Lyel
Kim Ji-Heui
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Abstract
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Background & Objectives: Little information about the incidence of retropharyngeal adenopathy and its impact on prognosis has been published. The purpose of this study is to investigate the incidence and prognostic significance of metastatic retropharyngeal adenopathy in patients with squamous cell carcinoma of the hypopharynx.
Subjects & Method: The pretreatment CT/MRI of 121 patients with squamous cell carcinoma of the hypopharynx were reviewed for the presence of metastatic retropharyngeal lymph nodes. All patients were treated between 1996 and 2005. The influence on recurrence (local and regional), distant metastasis, and survival was retrospectively analyzed. Mean follow-up was 28.3 months.
Results: Retropharyngeal node involvement was present in 21 (17.4%) patients. The clinical T staging was the most significant factor relating to the incidence of retropharyngeal adenopathy in multivariate analysis (p=0.006). The rates of regional recurrence and distant metastasis were significantly higher in patients with retropharyngeal adenopathy. Disease specific survival rate was significantly lower in the retropharyngeal node positive group (p=0.013).
Conclusions: Retropharyngeal node involvement has a negative impact on the prognosis of squamous cell carcinoma of the hypopharynx. Patients are particularly at risk for distant metastasis, resulting in worse disease-specific survival. Retropharyngeal node involvement should be taken into account in designing the treatment plan for these patients.
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KEYWORD
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Retropharyngeal lymph nodes metastasis, Hypopharyngeal squamous cell corcinoma, Prognostic factors
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